USMLE (United States Medical Licensing Examination) Step 1 Practice Exam

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What mutation is associated with the development of Pancreatic endocrine tumors, Parathyroid adenomas, and Pituitary tumors in MEN 1?

  1. MEN 1

  2. MEN 2a

  3. MEN 2b

  4. Pseudopseudohypoparathyroidism

The correct answer is: MEN 1

MEN 1 or Multiple Endocrine Neoplasia Type 1 is a genetic condition caused by a mutation in the MEN1 gene. This mutation is associated with the development of Pancreatic endocrine tumors, Parathyroid adenomas, and Pituitary tumors. It is distinct from MEN 2a and MEN 2b, which are caused by mutations in different genes and are associated with different types of tumors. Pseudopseudohypoparathyroidism, while a genetic condition, is not associated with the development of these specific tumors and is therefore not the correct answer.

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